- Simon Estes Amphitheater
- 75 E. Locust St., Des Moines, IA
- Simon Estes Amphitheater
- Walnut Street between 2nd Avenue and E. 1st Street, Des Moines, IA, 52309
- Simon Estes Riverfront Amphitheater
- 71 E. Locust St., Des Moines, IA, 50309
- Simpson Barn
- 6169 Northglenn Drive, Johnston, Iowa
- Simpson College
- 701 N C Street, Indianola, Iowa, 50125
- Simpson College West Des Moines Campus
- 1415 28th Street, Suite 250, West Des Moines, IA
- Simpson College's Kent Campus Center
- 701 North C Street, Indianola, IA
- SingleSpeed Brewery
- 303 Scott Ave, Des Moines, IA, 50309
- SingleSpeed Brewery
- 303 Scott Ave, Des Moines, IA, 50309
- SingleSpeed Brewery
- 303 Scott Ave, Des Moines, IA, 50309
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